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We have shown that monocyte invasion by T. annulata sporozoites activates hif-1α transcription and that HIF-1A remains induced even as transformed macrophage virulence is lost.
BiP remains induced after 24 hr of treatment, especially in cells treated with higher doses of F− (≥19 ppm).
Wnt reporter (TOPGAL) gene expression remains induced in the epithelial cells of the mammary bud through to E15 [ 4].
The expression of sterol-C5 desaturase (Sc5d) and Hsdh7 (Fig 2B and Fig 2E) genes, however, is significantly induced at the earliest time point and remains induced for the entire period of treatment.
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Although the mechanism for these differences remains unknown, hypoxia-induced metabolic depression likely plays a role.
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