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Further uncertainty remains downstream of Pitx2, where the target genes that facilitate asymmetric morphogenesis remain to be identified.
Furthermore, in the NBI a relatively large part of HV capacitance to ground remains downstream the core snubber, so neither the arc peak current nor the high-frequency oscillations can be effectively limited.
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However, the molecular mechanism responsible for MN formation remains unclear, as downstream centromere and kinetochore components of CENP-A remain unaffected.
When the cavitation number decreases, the cavity initially generates on the suction side of the blade near the leading edge and then expands to the outlet of the impeller, and the decrease of the total pressure coefficient mainly occurs upstream of the impeller passage, while the downstream remains almost unaffected by the development of cavitation.
Therefore, unless the frequency content of the stimulus remains fixed, or downstream neurons receive parallel information about the cut-off frequency of the input signal, the slope at burst onset cannot be decoded unambiguously by reading the number of spikes per burst.
However, what regulate the par genes upstream or what the par genes control downstream remains unknown in the oocyte.
Although the role of calcium signaling in the scale-feather switch remains elusive, several downstream effectors of calcium signaling play important roles in epidermal differentiation.
Contemporaneous archaeobotanical remains found downstream of the first cataract, from sites such as Tell el-Amarna (Fig. 1), are of the six-row type indicating that six-row varieties were available to the people of Qasr Ibrim and indeed were typical of Egypt then as now [14].
However, the direct downstream signaling remains unknown.
The production of biopharmaceutical proteins using plant-based systems has recently become economically competitive with conventional expression platforms based on microbes and mammalian cells, but downstream processing remains a significant cost factor.
It also remains open how the downstream brain centres would estimate the spectral power of the PN output if the presence or absence of oscillations was the main carrier of information.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com