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In contrast, bioengineering of entire soft tissue organs and, in particular endocrine glands still remains a substantial challenge.
The understanding and quantification of such flow effects remains a substantial challenge to the combat aircraft designer.
Producing accurate and reliable project cost estimations at an early stage of a project's life cycle remains a substantial challenge in the information technology field.
The use of tissue penetrant near-IR wavelengths enables in vivo applications, however the design of molecules that function in this range remains a substantial challenge.
However, the efficient incorporation of Uaas in response to the amber stop codon in mammalian cells remains a substantial challenge due to the competition from release factor 1 RF1).
Complete cure for psoriasis is still lacking and there remains a substantial challenge for world health systems to explore a new drug moiety or delivery system which could safely and effectively manage psoriasis without compromising patient compliance.
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Achieving competitive efficiencies and low manufacturing cost however remains a substantial research challenge.
While the rate of children at work is on the decline worldwide, child labour remains a substantial global challenge.
This means, that although a number of effective treatments are available, selecting appropriate treatment for individual patients remains a substantial clinical challenge for primary care where most patients are managed [ 5– 7].
Escherichia coli O157 remains a substantial public health challenge worldwide, particularly because of its association with hemolytic uremic syndrome (HUS) (1, 2 ).
However, its cost-effective fabrication still remains a significant challenge.
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