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This study confirmed that CYP3A5*3 is only suitable as a predictive marker for tacrolimus clearance, but close TDM remains essential due to the remaining variability between patients with the same genotype.
Potential explanatory variables that can explain the remaining variability in the point-level LUR will need primary data collection.
The data were then further stratified by the variables identified in the linear regression, and the remaining variability of commuting distances within each stratum was characterised by fitting a functional form to the distance distributions separately for each stratum with at least 5 individuals.
Since there is much less variation in how tall we are due to variability in diet, the remaining variability must be due to genetic variation.
It is expected that the CV will stabilise, which indicates that the variability due to cell size is small and the remaining variability is from the stand itself.
However, in some situations, mixing can explain the leading order variability in geochemical composition, while chemical reactions explain the remaining variability (Laaksoharju et al. 1999, 2008; Morales-Casique 2012).
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The remaining interannual variability is accounted for primarily through the annual intercepts, which will be discussed further in Section 2.6.
The remaining unexplained variability in 6MWT-distance might be found in the differences in skeletal muscle strength, the training levels and the physical activity levels of the participants.
After adjustment the remaining geographical variability in UMAs was modest at both the municipality level as well as at the local hospital area level.
The remaining phenotypic variability not accounted for by family effects was attributable to age and weight as well as to individual specific random environmental effects.
Penalized splines were used to capture nonlinearities in dependence, and thin plate splines of latitude and longitude were used to capture remaining spatial variability.
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