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We identified notably two highly conserved peptide sequences: the one is encoded by exons 3 and 4 (35 residues, 29 of them being conserved), and the other encoded by the 3' end of exon 5 and 5' extremity of exon 6 (22 residues conserved), that certainly play an important role remaining to be defined.
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However, the functional role of EpCAM in regulating cancer invasion remains controversial, and the mechanism(s) underlying EpCAM-mediated regulation of breast cancer invasion remain to be defined.
However, this remains to be quantitated and the kinetics of Kin5 synthesis and turnover within the cilium remain to be defined.
But Mr. Allawi's role in the new government remained to be defined.
He added that some crucial elements remained to be defined: how the force would be formed, who would contribute, and what its mandate would be.
Now at last she is in a position to make a contribution, but the nature, scale and direction of that contribution remain to be defined.
However, the clinical or physiological relevance of these extrapancreatic actions remain to be defined in humans.
In spite of some promising results, the actual pharmacological advantages of the hybrid agents remain to be defined.
Contributions of epithelial cell adhesion and contractility to the disease process of ARPKD remain to be defined.
The potential advantages of isoform-selective inhibitors over pan-HDAC inhibitors in terms of efficacy or toxicity remain to be defined.
The circulation rate and the clinical severity of infections caused by members of the new human rhinovirus C (HRV-C) species remain to be defined.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com