From this point of view, changes in melatonin receptor density in AD – increases in arterial MT1[ 274] and decreases in hippocampal MT2 [ 275] – may be less important than a remaining responsiveness of the SCN, perhaps in conjunction with the sedating effects of melatonin based on downregulation of neuronal NO synthase and actions on the GABAergic system [ 276].
Gfra2 null explants lose their responsiveness to NRTN, but remain responsive to GDNF and GDNF plus GFRa1.
Despite the large decrease in their excitatory synaptic inputs determined by the decreased dendritic spines density and the increase in minimal current to evoke the first EPSP, this increase in intrinsic excitability resulted in an enhanced responsiveness to their remaining synapses, allowing them to fire similarly or more efficiently following input stimulation than in control condition.
We demonstrated that, despite the large decrease in their excitatory synaptic inputs, this increase in MSN intrinsic excitability resulted in an enhanced responsiveness to their remaining synapses, allowing them to fire similarly or even more efficiently following input stimulation than in control condition.
The cellular and biochemical mechanisms that regulate how metastatic carcinomas lose responsiveness to anoikis remain poorly defined.
The precise molecular mechanisms by which MM cells show different responsiveness to cladribine remain unclear.
In addition airway responsiveness to methacholine remained stable in the BT group out to the last measurement performed at year 3 post-treatment.
In recent years, Bertolucci's responsiveness to beauty has remained strong, but his intellectual grasp of what he's doing has weakened.
Identification of disease-relevant serum biomarkers discriminating chronic colitis from other conditions, such as acute infectious colitis, or biomarkers identifying relative disease severity allowing non-invasive monitoring of disease progression and responsiveness to therapeutic treatments remain elusive.
Relaxation due to NO donors was also decreased by SRM1648, whereas responsiveness to cGMP analogue remained unaffected.
