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Besides the endpoints H and L, the endpoint E has the maximum consistency degree (0.979) of the remaining endpoints.
This study was not powered to formally compare FF with FP; furthermore, no consistent trend was observed in any treatment group across the remaining endpoints.
No statistical inference could be drawn for FF, vs placebo, for any of the remaining endpoints because of the statistical hierarchy.
There was no hypothesis testing or inferential assessment conducted for the remaining endpoints and the corresponding null hypotheses were not rejected.
Data were analyzed using a closed, step-down statistical hierarchy, whereby failure to achieve significance (P < 0.05) for the primary treatment comparison of FF vs placebo, at any point in the hierarchy, meant that statistical significance could not be inferred for the remaining endpoints, and these would be interpreted as descriptive only.
Similar(55)
The remaining secondary endpoints were exploratory.
One year after the third immunization titers had dropped, but all volunteers of groups B and E remained positive (endpoint titer >102) in ELISA.
As indicated previously, the FACT-ES and the Hot Flush Rating Scale will be used as the primary study endpoints, and the remaining measures will be considered as secondary endpoints.
Kaplan Meier survival curves represent the cumulative probability of an individual remaining free of an endpoint, in this case, death.
The main difference applies to polymorphisms in the evolved population, and any changes remaining polymorphic at the endpoint are likely of too weak a benefit to be detectable as compensatory by our test.
Beyond the study endpoint, the remaining gaps were further analysed in a post hoc analysis to determine if 'Minimum FTI' was still the predictive factor (as it was in EFFICAS I), or if secondary confounding parameters were discriminative for those gaps.
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