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Alternatively, the remaining disseminated and chemoresistant tumour cells, irrespective of their numbers, may have been the most important determinant of outcome.
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The model of BCG becoming more immune suppressive may also provide insight into why the extensively cultivated BCG daughter strains have remained effective against disseminated TB while losing their ability to protect against pulmonary TB.
In contrast, our proposed policy, QM-EBRP, works under quota protocols, meaning we take into account the number of existing replicas and the remaining replicas to be disseminated in the future.
Ten (59%) patients had CLABSIs (Table 2); the remaining 7 (41%) had disseminated (secondary) Nocardia bacteremia for which the respiratory tract (pneumonia) was the primary source.
The remaining 3 patients had disseminated disease without documented pulmonary involvement; one had fungemia, one had bone marrow involvement with fungemia and one had liver involvement with fungemia.
Significant progress continues to be made in detecting and treating breast primary cancer but the ability to predict the metastatic behavior of a patient's tumor and to eradicate or control recurrent disseminated malignancy remain major clinical challenges in oncology.
Although Arnt and Gdi2 have previously been implicated in cancer biology, the molecular mechanisms by which these proteins cause medulloblastoma cells to disseminate remain uncertain.
Although this is known as global information, QM-EBRP calculates this metric based on the remaining replicas that can be disseminated.
The disease was isolated to the transplanted kidney in 21 patients and disseminated in the remaining three.
In Nueva Ciudad, continuity was sustained by the administrator of the health centre who remained in the service and disseminated the knowledge and commitment among the new comers.
Despite high rates of adjuvant systemic treatment and breast irradiation in this series, disseminated carcinoma cells remain a prognostic factor, in favour of the resistance to treatment of locally or distant disseminated cancer cells in bone marrow-positive patients.
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