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In the current study we have shown that deletion of a specific tumor suppressor, Pten resulted in tumorigenicity specifically by promoting the emergence of a small number of highly tumorigenic ECC cells in vitro, while the remaining differentiated cells were non tumorigenic.
Also consistent with previous studies [24], [25], [30], about two-thirds of the differentiated cells were of the fast type that reacted with mAb F59 but not mAb S58 and thus expressed only fast MyHC s), whereas the remaining differentiated cells were of the fast/slow type that reacted with both mAbs F59 and S58 and thus co-expressed both fast and slow MyHCs (Fig. 3).
The predominant remaining differentiated cells at 40 days in the taurine/RA culture (i.e. rhodopsin-negative cells) were RPE65-positive cells (3.8±2.6%) (supplementary material Table S1, Fig. S2G).
This new process of cell adaptation to radiotherapy, which allows remaining differentiated cancer cells to acquire stemness, may probably contribute, together with clonal selection, to the stem cell compartment expansion inside the tumor after treatment and to the fast and almost inevitable recurrence of these tumors.
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In vitro cell culture revealed that chondrocytes could adhere, proliferate, and remain differentiated on the nanofiber-coated CMC-MCs.
Furthermore, they find that European nations are not converging toward one dominant egalitarian model but rather, remain differentiated by varieties of egalitarianism.
The publication does not aim at diagnosing the situation in each country separately but rather at confronting different perspectives applied to problems that resemble each other even if they remain differentiated in many regards.
The neurospheres remained differentiated neurons over the two-week cultivation in the multi-organ chip, proven by qPCR and immunofluorescence of the neuronal markers βIII-tubulin and microtubule-associated protein-2.
It is crucial for chondrocytes to remain differentiated to function properly.
If you can provide a higher-quality product or service than your competitors, you can remain differentiated.
Roberts discusses the extent to which Chinese food, as a facet of Chinese culture overseas, has remained differentiated, and questions whether its ethnic identity is dissolving.
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