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Changes in ScvO2, P(cv-a) CO2, and CRT appeared to become slower after 6 h, eventually representing the influence of non-flow dependent mechanisms on the remaining abnormalities [6],[27],[28].
The remaining abnormalities comprised non-sustained and sustained ventricular tachycardia, ST-T segment alterations, and cardiac conduction disorders.
Changes in ScvO2, P(cv-a) CO2, and CRT appeared to become slower after 6 h, eventually representing the influence of non-flow dependent mechanisms on the remaining abnormalities [ 6],[ 27],[ 28].
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Nevertheless, when the patients in remission who did not require treatment were studied separately, the only remaining abnormality was a reduction of the CD27 IgD IgM B cell-subset detectable in most of these patients.
The remaining cytogenetic abnormalities were characterized as normal or miscellaneous (any other abnormality).
The remaining five abnormalities were nonspecific (one central nervous system, one urogenital, and three 'others'others
We deliberately chose this strategy, since we consider it key not to replace therapeutic macro-hemodynamic strategies by micro-hemodynamic strategies, but to add micro-hemodynamic strategies in case of remaining microcirculatory abnormalities, despite optimal macro-hemodynamic resuscitation.
If cells were cultured in the absence of HU for 3 days after they were treated with 150 µM HU for 3 days, some of the nuclear abnormalities still remained but mitotic abnormalities disappeared.
The clinical efficacy was classified as follows: cure – all of the presenting symptoms and signs were resolved, and the laboratory tests and clinical procedures were normal; marked improvement – only one abnormality remained; improvement – at least two abnormalities remained at the termination of treatment; failure – clinical manifestations remained or were aggravated after 72 h of treatment.
By implementing an initial analysis with smaller windows, a large majority of abnormalities will be detected with highly specific boundaries before any remaining low-level mosaic abnormalities would be detected during the subsequent large window analysis.
The prevalence of any ECG abnormalities, and of repolarization abnormalities, remained significantly higher in the alternating hemiplegia cohort than in the disease control cohort if only the 47 cases with alternating hemiplegia with ATP1A3 mutation were considered (P < 0.0001 for both comparisons).
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