Sentence examples for remained refractory from inspiring English sources
Cancer is a multifactorial, resilient and extremely heterogeneous disease that despite intense research and specific successes has overall remained refractory to therapy.
Although vaccines have proven life saving against a myriad of infectious diseases, various pathogens have remained refractory to prophylaxis of their host by active immunization.
The synthesis of active Klebsiella aerogenes urease via an 18-subunit enzyme apoprotein-accessory protein pre-activation complex has been well studied biochemically, but thus far this complex has remained refractory to direct structural characterization.
More recently, mass spectrometry (MS -based MS -basedave been developed that provide low-resolution structural informethods whave contribeens to the developedthat of the native structure of provide complexes that have remained refractory to the high-resolution methods.
The mononuclear cells did not proliferate and remained refractory.
As the severe itching remained refractory despite any pharmacological treatments, we performed peripheral branch neurolysis therapy for this patient.
Despite the equivalent efficacy and better tolerability of these drugs, more than 25% of patients remain refractory to treatment.
Treatment of chronic wounds can present a challenge, with many patients remaining refractory to available advanced therapies.
Despite the introduction of antiepileptic drugs (AEDs) in the past 20 years, the seizures of around 30% of patients with epilepsy remain refractory to available treatment.
A series of 47 adenosine analogues was prepared with modifications at the 2-, 6- and 5′-positions, based on the hypothesis that such compounds would serve as substrates for protozoan nucleoside salvage enzymes, while remaining refractory in mammalian cells.
Patients who remain refractory to twice-daily PPI therapy should undergo esophageal ambulatory pH monitoring while on therapy to determine whether appropriate acid suppression has been achieved and whether the patient's symptoms are in fact a result of gastroesophageal reflux.
