The results remained in principle unchanged, if the values were normalized to input DNA directly (compare Figure 6 and [Additional file 1: Figure S4A]).
Darwin depicted the gradual complexification of the organ of visual perception from a light-sensitive spot to a fully-fledged eye; in this example, the function of the organ, while evolving, remained, in principle, the same.
However, semantic and foundational theories remain in principle different and designed to answer partly non-overlapping sets of questions.
While in such cases, the alternatives that we are compelled to avoid remain in principle open to us the offer is not physically imposed on us, it is just bad the same could be said of most literal coercion.
The Dutch Act states that, although voluntary euthanasia and assisted suicide remain, in principle, criminal offences, physicians will not be prosecuted if they have reported to the committee and the committee finds that they have acted with due care.
But the previous administration remained committed in principle to destroying the virus, a commitment that the Bush administration has now refused to make.
The speeches made clear that despite surviving two assassination attempts last month, General Musharraf remained wedded in principle to a moderate, tolerant Islam and to keeping Pakistan in the international community's good graces.
Prince Saud said he remained opposed in principle to the use of military force or a unilateral attack by the United States, but his remarks seemed to indicate an important shift in Saudi Arabia's posture.
Further, deeper justifications in terms of esoteric philosophical theory would, of course, be welcome, but only insofar as they remained consistent in principle with public "mid-level" justifications of the same policies.
Three of Pollock's textbooks remained in use for many years: Principles of Contract (1876), Digest of the Law of Partnership (1877), and The Law of Torts (1887).
Yet, while as we have seen (section 3), Hume certainly saw it as part of the road to "true philosophy," he does not view Newton's achievement as a decisive advance in knowledge of nature but, instead, as decisive evidence for the claim that nature will remain unknowable in principle.
