Although the ED can be implemented without any need of apriori knowledge of the PU signal, some difficulties still remain for implementation.
By simulation of alternative dose regimens we demonstrated that an increased dosing interval of 2 g cefazolin every 6 hours (instead of 8 hours) yielded prolonged therapeutic concentrations, based on the expected MIC90 value of 4 mg/L, yet remained feasible for implementation in daily clinical practice.
While California is developing mechanisms for assessing effectiveness of the MPA network in coming years, including establishing a MPA Monitoring Enterprise and a process for periodic review and adaptive management of MPAs, significant challenges remain for effective implementation.
There are many elements that imaging can aid with in diagnosing these complicated disease processes; however, many challenges remain for the implementation of efficient and safe use of pediatric imaging in the developing world.
Although the overall turnaround time for metagenomic sample-to-detection has now been reduced to <6 hr with nanopore sequencing, many challenges remain for routine implementation of this technology in clinical and public health settings.
However, challenges remain for its practical implementation, considering the number of assumptions and magnitude of deviations to be considered.
Problems do remain after implementation, for example concerning safety/security-related issues and inaccessible entrances and indoor environments.
Despite the significant conceptual promise of comparative proteomic profiling as a research platform for biomarker discovery, however, major hurdles remain for practical and clinical implementation.
At this point, it can be concluded that utility-side renewable energy business models offer various advantages for utilities, whereas several problems remain for utilities concerning the implementation of decentralized small-scale renewable energy business models.
Several areas remain for further refinement of our implementation of pooling-based statistical analysis of microarray data.
That probably will remain the target for implementation of the measure, although some of those close to the deliberations said they do not completely rule out an attempt being made to have the proposal take effect next season.
