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Even after 20 cycles of replacements, we found ∼50 70 regions of 10 100 kb where the initial uneven coverage of the N2 sequence had nucleated improved coverage after the iterative correction/extension approach, but overall coverage of the region remained discontinuous; ALE and REAPR scores remained high in these regions.
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Moreover, treatment of endothelial cells with the Rho-associated coiled-coil kinase (ROCK) inhibitor Y-27632 significantly reduced the number of discontinuous AJs, although the overall level of junctional VE-cadherin remained unaltered, suggesting that discontinuous AJs are formed in response to stress fiber-induced tension acting on cell-cell junctions.
The highway section in Kent County remained marked as M-91, resulting in a discontinuous highway.
In gelatin + soy + starch mixtures, the gelatin and soy remained mixed as the continuous phase and starch existed as the discontinuous phase.
In sections, the reporter expression appeared in a discontinuous pattern within a subset of luminal cells and was absent from alveoli, which remained morphologically distended.
Lymphocyte surface activation markers or cell-bound HIV DNA levels remained stable or declined further; CD4/CD8 ratios rose to ≥1 in 37% of patients – versus 7% patients before discontinuous treatment.
By 1642 Dutch navigators had discovered discontinuous stretches of the western coast of Australia, but whether these coasts were continental and connected with the hypothetical southern continent of the Pacific remained unknown.
Nevertheless, discontinuous bevacizumab would remain the most cost-effective strategy even if there were no difference in quality of life between treatment regimens.
Importantly, in areas with remaining ILM, the ILM showed a discontinuous, netlike pattern (Fig. 1D″).
Each saltational species exhibits a markedly different and discrete example of discontinuous trait evolution while remaining canalized for other typical traits shared by the rest of the genus.
It is not, Dedekind stresses, necessary for space to be continuous in this sense, for "many of its properties would remain the same even if it were discontinuous".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com