In agreement with another Caucasian series of T1D children [17], the prevalence of ZnT8A remained substantially stable in patients up to four years from the clinical diagnosis, but then showed a significant decrease, and the ZnT8A remained finally appreciable in approximately 34%% of patients evaluated ≥5 years from diagnosis.
a The percentage of positive ZnT8A patients remained substantially stable up to 4 years from diagnosis, then decreased significantly in patients analysed ≥5 years from diagnosis (79/133, 59.4 % within 4 years versus 27/80, 33.8 % in ≥5 years patients; *p = 0.0004, 95 %CI 1.61 5.12, OR 2.87).
The sensitivity of ZnT8A at disease onset was 61.1 % (similar to that showed for GADA) and remained substantially stable in patients analysed after one up to 4 years from diagnosis (56 and 59.3 %), then dropped down significantly in patients ≥5 years from diagnosis (33.8 %; Fig. 2a).
Total IgM, IgG and IgA remained substantially stable in OBS subjects for most of the follow up (Fig. S3 C E), whereas a significant reduction of total IgG was recorded early after immunization in trial subjects (Fig. 7 A C).
Patients showed a significant DAS28 reduction at T3 (P < 0.0001) and remained substantially stable at T6.
It is of note that the percentage of anti-CCP2-positive patients and anti-CCP2 titers remained substantially stable during follow up (data not shown).
Of importance, the degree of anisotropy of water diffusivity remained substantially stable in the mice that we have studied upon myositis induction, contrasting sharply with MRI results obtained in CTX-treated mice.
Conversely, GC formation is certainly the first response to micro-vascular aggression and damage [ 17], but they may remain substantially unchanged when repeatedly observed in NVC in a slowly evolving or stable disease [ 18].
In contrast, cis-aconitate pools were relatively similar and stable in control and elicitor-treated cells, but remained substantially higher in elicitor-treated cells at 80 and 100 h.
