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This, however, makes clear the limitations of using data on drug efficacy in children to derive drug treatment policies in pregnant women, and it strengthens the fact that combinations containing older drugs which are losing efficacy in children may still remain efficacious in pregnancy.
Just how abbreviated, though, such repeated workouts can be and still remain efficacious isn't yet clear.
In parts of West Africa where SP and AQ both remain efficacious, the combination AQ+SP could be considered for first line treatment for uncomplicated malaria.
PA7 complexes have a strong propensity for aggregation under physiological conditions (due to their premature conversion to the channel state), suggesting that the toxin requires additional stabilization mechanisms to remain efficacious during infection [21], [22], [30].
It is generally understood that LLINs remain efficacious for at least 3 years, however more understanding regarding how long these LLINs remain viable in actual living conditions is needed to inform ITN procurement and distribution systems and maintain high population coverage.
It is assumed that KMC, shown to be effective for managing pain in neonates during single events, will remain efficacious over time.
Similar(46)
Importantly, the TERISA trial provides data suggesting ranolazine remained efficacious when added to ∼90% β-blocker background therapy.
However, further investigation is needed to establish how this treatment contributes to neutropenia and which doses of each compound are best tolerated while still remaining efficacious.
The aim was to establish whether a previously validated computerized program (The Sadness Program) remained efficacious when delivered via a mobile application.
Of note, linagliptin remained efficacious across the treatment spectrum, including in patients who had longstanding diabetes and those treated with insulin.
31, 35, 36, 39– 43 Importantly, impacts of pfmdr1 polymorphisms on drug sensitivity are modest, correlations between particular polymorphisms and treatment efficacy have not been seen, and the ACTs artesunate/amodiaquine and artemether/lumefantrine remain highly efficacious for the treatment of uncomplicated falciparum malaria in Africa.
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CEO of Professional Science Editing for Scientists @ prosciediting.com