Sentence examples for remain deleterious from inspiring English sources

Even successful flavivirus infectious cDNA clones constructed in low-copy number plasmids remain deleterious to E. coli, leading to slow growth and poor DNA yields [5].

In particular, as σ g 2 increases P SGV decreases, because most large-effect alleles remain deleterious even if environmental change is fast.

Thus, if simultaneous evolution at many loci allows the population to closely follow the optimum, large-effect alleles at any given locus are likely to remain deleterious (as their carriers would overshoot the optimum).

The remaining deleterious SNPs that are heterozygous, include rs2108622 [19:g.15990431C > T] [Val433Met] (CYP4F2 gene [MIM: *604426]) that is associated with Warfarin drug response and altered Vitamin K (VK1) metabolism.

The remaining deleterious mutations were found in the orphan G-protein coupled receptor, Gpr126 (Gly196and), and synaptic nuclear envelope protein 1, Syne1 (Arg386Gln), with the deleterious variant in both cases found in DBA/2J.

In other words, genome growth can be a species-level adaptive consequence of ancestral TE suppression mechanisms, while the majority of transposition events remain mildly deleterious at the level of organisms.

All of the remaining six deleterious variants that were not reported in either of the databases were predicted to be protein truncating (nonsense, frameshift, or splice-site variants).

All of the remaining predicted deleterious variant that do not have disease or trait associations (namely, category 4) are listed in Additional file 2: Table S7.

Cryptic Alu exons that are deleterious will remain suppressed; however if an exon becomes less deleterious by chance, selection against exonization will be considerably reduced.

Yet international duties towards the minimum core remain significantly underspecified, with deleterious impacts on the realization of minimum core obligations in low and middle-income countries.

Indeed, accumulative clinical studies pointed out that positive fluid balance and weight gains are associated with a worse prognosis [ 12] but the mechanisms of this deleterious effect remain unknown.