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Owing to their hypovascularity and hypocellularity, tendinopathies remain a substantial challenge for both clinicians and researchers.
The destabilizing effects of biological invasions on host parasite relationships remain a substantial challenge for future research.
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However, their analytical applications still remained a substantial challenge of relatively low ECL intensity.
Substantial progresses in the design of cheap, robust, and efficient catalysts are still required and remain a significant challenge.
However, although the complexity is arguably reduced, genetic heterogeneity may still remain and can pose a substantial challenge for conventional pedigree-based methods, such as linkage analysis.
Despite considerable effort, standard technical definitions have remained controversial and the widespread use of generally accepted testing protocols has proven to be a substantial challenge that is not yet resolved (Borgert et al. 2011b).
Hackett faces a substantial challenge.
For the school leaders involved, forging these partnerships presents a substantial challenge.
The fact that Cox doesn't is hardly a substantial challenge to that statement.
Yesterday, Jordan was upbeat and eager to put his arms around a substantial challenge.
9 We thus are faced with a substantial challenge.
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