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We show for the first time that a relocation of specific histone modifications takes place during activation of genes.
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Conventional cell-based assays generally measure a single cellular event, such as the generation of a second messenger or the relocation of a specific protein target.
To resolve (part of) these latter aspects, it would be of great value to have a signal-transduction system available that can be triggered with (a flash of) visible light, and that initiates relocation of a specific component of that signal transduction network in the cell, like e.g. between subcellular compartments.
These changes were also accompanied by downregulation of the transcriptional activity and relocation of the keratinocyte-specific gene loci away from the sites of active transcription toward the heterochromatin-enriched repressive nuclear compartments in p63-null cells.
We show that a specific relocation of these PTMs correlates with gene activation.
As the taxon sampling of available Spiroplasma genomes continues to improve, it will be interesting to investigate if this relocation of the map gene is specific to the Citri clade or shared by other Spiroplasma lineages.
Renal ischaemia disrupts the cytoskeletal architecture resulting in relocation of apical and basolateral membrane-specific proteins such as ankyrin, fodrin and Na+ K+ -ATPase.
Moreover, there has been a strong focus on the impact of specific life events such as childbirth or residential relocation on mobility practices of individuals and households.
Wasmer (2006), in turn, emphasizes that, by inducing substitution of specific for general skills, stringent EPL hinders worker relocation across industries in the presence of sectorial shocks.
Although level shifting of specific explanatory factors seems to work less easily within purely physical explanations, relocation attempts involving broad physical principles can sometimes avoid such difficulties.
The few exceptions that are tissue-specific apparently correspond to the relocation of pre-existing TADs to the nuclear lamina (Fig. 2D).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com