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Further, the altered disorganization and relocation of proteins that participate in secretory granule formation are also dysregulated in Sjögren's syndrome and will contribute to abnormalities of mucins within the extracellular matrix.
During differentiation, relocation of proteins from the pericentriolar material to the nucleus starts at an early stage, before fusion of myoblasts into myotubes [8].
Likewise, the accumulation of MglA/GTP at the lagging pole during a reversal induces the relocation of proteins from the leading to the lagging pole and vice versa.
Different types of radiation can cause nucleolar segregation, nuclear relocation of proteins, and changes in protein post-translational modifications [ 4, 6, 8, 23– 28].
Nucleoli were fragmented and the relocation of proteins involved in transcriptional silencing from telomeres to the nucleolus was revealed in both the haploid and diploid state.
Protein transport apparently has also been affected, the relocation of proteins to new sites for defense was evident by the down-regulation of B14 protein (AK061365) (Table 2) involved in peptide transport from ER to golgi and up-regulation of a DnaJ like protein (AK069823), two peptide disulphide isomerases (PDI) like proteins (AK068268, AK069583) and a peptide-proton symporter PTR2 (Table 1).
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Nucleolus fragmentation, changes in the nucleolus size and the nucleolus/nucleus ratio, ERC accumulation, expression pattern changes and the relocation of protein involved in transcriptional silencing during CA were revealed.
Furthermore, induction of gametogenesis following gametocyte activation results on the one hand in the destruction of the gametocyte IMC and relocation of cytoskeletal proteins [ 7, 33, 34, 72, 73], on the other hand in a drastic turn-over of surface proteins (reviewed in [ 6]).
Proper rearrangement of F-actin is the key for cell movement and directional relocation of signaling proteins [30], [38].
Another early event of myoblast differentiation is the relocation of centrosomal proteins to the nuclear surface.
Further accumulation of MglA/GTP induces reversals by stimulating pole-to-pole relocation of motility proteins.
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