The atoms are then relocated towards the global optimum point in the atom relocation phase, navigated by other atoms' trajectory.
Following the model by Autor and Dorn (2013) and later revisited by Cortes (2016), it is expected that middle workers relocate towards bottom-paid occupations, under the assumption that its relative comparative advantage is higher in manual than abstract tasks.
Antique specimens from Tyrol show two variants (Fig. 3c): in the left one, the upright post holding the string with the latch is relocated towards the front; in the right one, it is replaced by two upright posts and an overhead beam forming a frame.
Interestingly, when compared with MnmE, helix α2 that presents Asp-57 is relocated towards the N-terminus in YqeH.
For the same reason, helix α2 in YqeH is also relocated towards the N-terminus where it is connected to a Zn finger domain (Fig. S3).
Adding to this, the region corresponding to helix α2 is relocated towards the N-terminus owing to the circular permutation (Fig. 1 & 6a), making the identification of the catalytic residue a non-trivial exercise based on sequence information alone.
While T cells' Golgi apparatus and MTOC are relocated towards the intercellular junction in T cells establishing immunological synapses [27], [28], analogous cytoskeletal and organelle reorganization of target cells post-synaptic to CTL Kupfer-type immunological synapses has not been studied.
Superposition of the G-domains of MnmE (transition state) and YqeH (GDP-bound) showed that while switch-II in MnmE is continuous with helix α2, in YqeH, owing to the circular permutation, it is relocated towards the C-terminus and is connected to the C-terminal PNR domain (Fig. S2 & S3).
The myosin ring colocalizes with actin (cyan arrowheads) and relocates towards the equator (yellow arrowheads) during cell elongation.
In YqeH, like the other cpGTPases, switch-II, a region important for GTP binding and hydrolysis, is relocated towards the C-terminus of the CPG-domain owing to the circular permutation [2].
