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It has developed a mechanism called trans-translation to add a short peptide tag to the partially produced toxic proteins so that they can be recognized for degradation by proteases to relieve the toxicity.
Therefore, pumping intracellular lovastatin out of the P. pastoris cell through an efflux protein may relieve the toxicity effect and metabolic stress; as a consequence, the productivity of yeast cells may improve too.
Therefore, specific interruption of the HDAC4-MAP1S interaction with short peptides or small molecules to enhance autophagy flux may relieve the toxicity of mHTT associated with Huntington's disease and improve symptoms of HD patients.
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Over-expression of MOP2 relieved the toxicity caused by the over-expression of PMA1 from a high copy plasmid; conversely, the growth of mop2 strains was inhibited by the presence of a single extra copy of PMA1.
Using a non-transcriptional readout enabled us to examine the interactions of a transcriptional activator and moving interaction interrogation to the Golgi seems to have relieved the toxicity that is normally observed with Gal11p overexpression.
Spotting assays demonstrated that an extra copy of GAL80 relieved the toxicity of 0.05% galactose in both parental strains.
Among the HSP40s in Drosophila, DNAJ-1 has key role in relieving the toxicity of aggregated proteins, whereas other DNAJ proteins such as DROJ2, CG5001, and CG2887 lack this function (see Table 1; Supplementary Figure 4).
N-guanyl-1,7 diaminoheptane, a specific inhibitor of eIF5A hypusination, partially relieved the toxicities of both amino acids and polyamines.
Export of these compounds may relieve the cellular toxicity and increase the yield.
Wang et al. [ 11] observed that PAP1 expressed at a higher level in Al-tolerant than in Al-sensitive rice root, suggesting that Al-tolerant cultivar might relieve the Al-toxicity through improving the P acquisition.
Patients with necrotising fasciitis are early submitted to surgical debridements of the affected areas in order to remove all non-viable tissue and help relieve the cause of systemic toxicity [1]. 1. Loss of oral cavity or pharyngeal mucosal integrity.
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