Sentence examples for relieve interactions from inspiring English sources

Together these observations support the initial experiments by Walden and co-workers [ 28, 123] that showed parkin, and now other RBR E3 ligases, exist in an auto-inhibited state that must undergo significant conformational change to relieve interactions of the Ubl and RING0/Ariadne/helical base domains to support ubiquitination.

By contrast, the better-defined structure for subunit A of the L6RM shows the carboxylate side chain of E168 displaced toward solution, compared with wild-type cTIM, probably to relieve destabilizing interactions with the side chain of E129.

It is possible that hypoxia (and also dense intercellular contacts) upregulate expression of endosialin to relieve pericyte endothelial interactions and/or to modulate local tumour stroma, and thereby facilitate migration of dividing endothelial cells and sprouting of new blood vessels.

If the altered cell wall organization observed in the vti13 mutant contributes to its growth phenotype in root hairs, lowering the pH in the growth medium may help relieve aberrant interactions between wall polymers and result in root hairs whose length is more similar to those of wild-type seedlings.

Epistasis refers to the phenomenon in which the phenotypic consequence of altering one gene is differentially modulated by the specific alleles of a second one, including both negative (aggravating) interactions and buffering (relieving) interactions [21].

For ubiquitination to proceed, structural studies have shown that a significant conformational change must occur, in part to relieve the interaction of the Ubl domain with the RBR region of parkin.

It has been proposed that the interaction of Rho GTPases might relieve an intermolecular interaction between exocyst subunits that would lead to its activation.

The State*Trend interactions relieve the statistical model of the parallel trends assumption, that is, it allows that workers located in different states may experience different wage trends.

Inhibition can be relieved by interaction with a non-active USP, such as USP39.

Interestingly, this inhibition is relieved upon interaction with Exd, highlighting the influence of the environment on the SLiM inhibitory activity.

We further show that unfolded protein CH1 binds to the canonical BiP substrate binding domain; this relieves the interaction between BiP and luminal domains of Ire1 and Perk.