As a result, unimportant genes can be reliably disrupted or deleted but not edited.
Upon retesting, the third RNAi line against bbg (v101691) did not reliably disrupt migration.
For better or for worse, the Grammy tally will be used as a measuring stick for future generations to understand the past, and when it's flawed, as it reliably is, it disrupts the proper writing of history.
It is, however, difficult to estimate reliably the extent of the disrupted region (Siebner et al. 2009; Ziemann 2010; Möttönen and Watkins forthcoming).
In particular, we found that most of the proteins encoded by RSV (98.1%) and SM genes (98.2%) were not affected by potentially disrupting mutations and were reliably transferred to the corresponding genomes.
CRISPR/Cas9 generally disrupts their intended target sites reliably; however, an important question to consider is to what extent these nucleases induce off-target cleavage events, especially in therapeutic application.
The variant caller could not detect copy-number losses and gains reliably in FFPE samples because of the highly disrupted signal, and visual inspection was not possible due to the waviness of the Log2 ratio.
Newborns do not sleep reliably, and they must eat frequently, which can disrupt their mothers' sleeping patterns.
Even in reliably red Texas, even for a generation eager for a candidate who disrupts and discomfits the ossified Washington establishment, Trump is a hard sell.
An alternative conclusion is that any mutation that disrupts the fidelity of endocytosis may well disrupt the ability to reliably generate small vesicles of a consistent size.
There is an increasing need for effective biomarkers which can reliably predict the response to novel therapeutics acting as angiogenesis inhibitors or as vascular disrupting agents in vivo, and the RGD-based ligand, [18F]fluciclatide, is very promising in this respect.
