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Decreasing variability in PK parameters improves our ability to develop dosing regimens that reliably achieve therapeutic targets.
Then, its devices are managed and a demonstrator is presented to show that the framework was able to reliably achieve the target objectives.
54, 55, 56 High between‐subject variability in busulfan pharmacokinetics makes it challenging to reliably achieve this target with the FDA‐approved dose of 1.1 mg/kg for children ≤12 kg and 0.8 mg/kg for children >12 kg.
Things like dedication, goal-setting, and focussing on achieving targets.
Public commitment to achieving targets is important.
Following target setting, activities were planned to achieve targets.
At a 24-hour dosing interval, Monte Carlo simulations predicted target gentamicin peak and trough concentrations could not be reliably achieved at any dose.
The last of these requirements is noteworthy the argument needs to rest on PK data from patients with the target syndrome (or with metabolic disturbances similar to those of patients with the target syndrome) plus a demonstration that most (usually taken as ≥∼90%) of subjects will reliably achieve that exposure relative to the expected range of MICs.
We conclude that regulating or taxing observable emissions would more reliably achieve emission reduction.
The clock created a standard for time keeping, a public accounting that could not be reliably achieved with hourglasses or sundials.
Receiver operating characteristic (ROC) analysis demonstrated that MCI diagnosis could be reliably achieved based on the combination of indices of multisensory integration together with indices of sensory dominance.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com