Sentence examples for reliable readout from inspiring English sources

This sensor responded to defined perturbations of the BMP-Smad pathway (Supplementary Figure 7), indicating that it serves as reliable readout for endogenous signaling.

We first tested the effect of expression of exogenous PIAS1 on an E-cadherin promoter driven luciferase reporter gene, whose repression represents a reliable readout of EMT [47], [48].

We have developed a novel genetic screen to identify genes associated to neurodegeneration based on the concept that behavior provides a reliable readout of the state of the underlying neuronal circuit.

While this may be essential for host cell viability, it is not clear that it is essential for expression of retroviral genes, thus siRNA screens designed with tat-mediated expression of a reporter gene may not provide a reliable readout for factors involved in post-integration DNA repair.

As the wing margin formation is not a reliable readout for activated Notch signaling, we investigate consequences of manipulated CG32479 expression on scutellar bristle differentiation.

These data suggest that this assay could be used as a reliable readout to identify new factors that are part of, or control, the core mitochondrial fusion machinery.

These results establish that the 3 × 69-VNP and per-TdT reporters provide reliable readouts of the molecular clockwork at a single-cell resolution; 3 × 69-VNP reports CLK/CYC-mediated transcriptional rhythms and also mimics per mRNA rhythms, whereas PER-TDT mimics PER protein oscillations.

In order to isolate independent signalling modules, there is a requirement to identify simple and reliable readouts.

However, few studies have addressed the functionality of these transitory states, an oversight partly caused by the lack of a detailed understanding of EMT and the current dearth of reliable readouts for its progression.

The data in Figure 1 therefore indicate that RNase activity and OD500 provide reliable readouts for Ire1KR32 oligomerization and support the model [ 8] in which oligomerization and RNase activation are mechanistically coupled.

Although mouse phenotypes have been identified that meet these criteria (Table 2; supplementary material Tables S3 S7), some phenotypic domains, particularly those involving complex behaviors (e.g. social behaviors and anxiety), still lack consistent, reliable readouts in current RTT models.