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A reliable progression marker would make it possible to conduct shorter trials, on a smaller number of patients, thereby opening up the prospect of more diversified trials [ 19, 20].
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Since the reliability of such estimated progression rates is affected strongly by the number of available creatinine values (with fewer creatinine measurements resulting in less reliable estimates of the true progression rate), participants with fewer than 3 follow-up creatinine measurements were excluded.
Unfortunately, to date there is no reliable predictor of progression to NASH, nor are therapies approved by the U.S. Food and Drug Administration for this condition.
In both univariate and multivariate analyses, the RRI was shown to be the only reliable predictor of progression of renal disease in patients with renal artery stenosis and identified those whose blood pressure and renal function was unlikely to improve with intervention[ 1, 22, 23].
Over a period of between one and a half to six years, declines in reconstructive memory processes were reliable predictors of future progression from healthy aging to mild cognitive impairment and Alzheimer's dementia, and better predictors than the best genetic marker of such diseases.
While reliable measures of disease progression are important to guide which treatments to study in trials, clinical outcome trials must remain the basis for informing clinicians on which treatments improve clinical outcomes.
Sentinel node status is not a reliable predictor of disease progression in patients with nodular melanoma.
In contrast, focally increased FET uptake is an early and reliable indicator of tumour progression.
Can the measure of Insightful Practice offer a reliable recommendation on students' progression in training?
They concluded that Cho/Cr and Lac/Cr appeared to be reliable biomarkers of tumor progression.
Muscle wasting due to CNS damage is a reliable indicator of EAE progression.
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