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The most reliable clue for guessing the function of putative genes is protein sequence similarity to well-investigated gene products, but such annotations have to be interpreted with caution.
> -wrap-foot> Trackingenenexpressionon patterns can be a reliable clue for deducing the function of a given gene, as cells change their gene expression in response to environmental perturbations.
Other studies have shown similar male preponderance [ 10, 37], concurrent hazardous use of alcohol and other illicit drugs [ 8, 11, 15], with studies suggesting that smoking is a reliable clue for other substance use and abuse [ 8] including alcohol [ 40, 41].
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These models (2D & 3D) were found to yield reliable clues for further optimization of benzimidazole derivatives in the data set.
The computational approach used in this paper provides reliable clues for further design of small molecules gp120/CD4 inhibitors based on the BMS-806.
This model (3D) was found to yield reliable clues for further optimization of fused 5,6-bicyclic heterocycles in the data set.
The ability to correctly estimate big maneuvres is especially important for the integration with offline map data, as maneuvres are generally more reliable clues for map matching than gentle curves and straights.
Taken together, the present QSAR models were found to accurately predict the PDE10A inhibitory activity of the test-set compounds and to yield reliable clues for further optimization of the quinazoline derivatives in the dataset.
The CQI provides unique and reliable clues for inferring some roles of proteins whose functions are unknown.
Although this holds true for Neuropad interpreted for screening purposes as normal or abnormal after 10 min of application on the plantar aspect of the feet, there is evidence that prolonging the time of observation after application might be useful in increasing the sensitivity for neuropathy and in providing a reliable clue to the severity of neuropathy (6, 8).
A more reliable clue to why we yawn may come from when, precisely, we do so.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com