In contrast, the most intense and reliable alterations in [DA] were observed upon reinforcement in the DLS of rats self-administering 10S and 10S10E.
Distinct gene expression differences, such as the loss of p16 in the tumour samples demonstrate reliable alterations, but the results are more debatable where only slight differences were seen.
Reliable genetic alteration profiles, however, can be of great interest as predictive markers of patient outcome regardless of its influence on gene expression; and DNA is relatively easy to handle and more stable than RNA.
Gel spots demonstrating consistent (reliable direction of alteration, i.e. up or downregulated by ≥20%, n = 6) differential expression from DIGE staining were excised, incubated with iodoacetamide and digested with sequence-grade trypsin (Promega Corp., Madison WI) overnight at 37°C.
On data obtained from high-throughput sequencing, improving quality through GC bias correction and keeping false positives to a minimum help build reliable copy number alteration profiles.
Careful comparison of global transcriptional patterns in two well-studied clones of P. falciparum (Dd2 and HB3) indicates that reliable, stable transcriptional alterations in malaria can be readily distinguished from stochastic processes.
The FMR, a reliable marker of alterations of fat distribution [ 13], was in the normal range for both men (below 1.5) and women (less than 1.0) in the two treatment groups.
Sari et al. (2017) observed a linear relation between contact angle and ζ-parameter (a combination of rock-brine and oil-brine ζ-potential), stating that ζ-potential is a more reliable means of wettability alteration prediction rather than brine salinity because different salinities of different ions may result in the same oil recovery.
The most comprehensive and reliable analysis of genomic alteration in primary GBM tissue has been conducted by The Cancer Genome Atlas Research Network (TCGA) [97], a collaborative project sponsored by the National Cancer Institute (NCI), National Institutes of Health in USA [97].
More than three decades after Johnstone's first computerised axial tomography of the brain of individuals with schizophrenia [ 1], no consistent or reliable anatomical or functional alterations have been univocally associated with any mental disorder and no neurobiological alterations have been ultimately confirmed in psychiatric neuroimaging.
