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Sensitivity, specificity, PPV, and NPV were analyzed to determine the reliability of predictors of the response to therapy.
De Bruijn et al. recently supported this result with their retrospective study from 2012 on the reliability of predictors for cut-out by identifying the central-inferior and anterior-inferior positions as being highly protective against lag screw cut-out [ 32].
The need to estimate the potential functional impact of any non-synonymous variant is hence a priority and yet the discrepancy of their pathogenicity predictions (Thomas and Kejariwal 2004; Adzhubei et al. 2013; Capriotti et al. 2013), when different algorithms are used, highlights the need for methods that may weigh the reliability of predictors and yield a single pathogenicity score.
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According to methodological standards for the development of clinical decision rules in the Emergency Department, the reliability of predictor variables should be tested by determining the intraobserver and interobserver agreement [ 25].
We evaluated the accuracy and reliability of 11 predictor variables used in the evaluation of patients with syncope and developed a highly sensitive clinical decision rule that may be used to augment physician judgment and allow physicians to rationally decide which patients with syncope may need admission according to their risk for short-term outcomes.
We assessed the interobserver reliability of the predictor variables by having an independent second physician repeat the assessment of the patient.
Aside from the accuracy measures (validity), the reliabilities of the predictors were also determined using Shannon entropy as a measure of uncertainty.
The reliability of ProsaII-based predictors is marginally impacted by the subset of residues taken into account, as reflected by their success rates: 60% for All, 50% for ROI and 50% for SSE.
7 Consequently, whether exposure and its predictors are reliably measured in observational studies is difficult to decipher, and thus, approaches which reveal the validity and reliability of estimates and predictors are required.
The higher than average phenotype probabilities and the enrichment for high probability genes at the vicinity of GWAS SNPs (Fig. 3C) support the reliability of our phenotype predictors as well as the quality of association data.
The purpose of this study was to test the reliability of the Resuscitation Predictor Scoring (RPS) Scale1 (Appendix A), a survival prediction nomogram designed to aid resuscitation termination decisions during a resuscitation attempt.
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