As indicated, for example, in [21], the use of weighted coefficients for previous values increases the accuracy and reliability of predictive events.
The precision and reliability of firing events [20] [22] were characterized by measuring the trial-to-trial jitter in response to intensity steps.
In our study, both signalling mechanisms tested used the same remote monitoring platform, which has excellent transmission reliability, delivering >90% of event notifications in <4 min and is approved specifically for early detection.
An edge between a TF and a gene indicates that the TF likely binds to the promoter of the gene as based on the ChIP-chip experimental results [ 9, 10], and the edge weight reflects the reliability of a binding event between a corresponding TF and gene pair.
The second caution, however, calls into question the reliability of dating coalescent events.
The changes in the protocol and the instrument are focussed on the improvement of the quality, efficiency and reliability of the adverse events determination and their preventability.
We evaluated the number and the consistency of the best hit to determine the reliability of the fusion/splitting events (see Methods).
On the one hand, the quality of the diagnosis encoding varies according to the experience and expertise of coders [ 38], making it difficult for data analysts to adjust the validity and reliability of the reported events.
Also in the previous studies inter-rater reliability appeared to be a major problem [ 1- 3, 9, 11, 17- 19] Therefore, standing on the shoulders of our predecessors and keeping the method and instruments maximally comparable, we have tried to improve the reliability of the adverse events determination.
