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This information is relevant when evaluating the resolution power of the selected combination of markers, and hence their applicability and informativeness in genetic analyses [35], [36].
The complexity of chronic pain suggests that multiple domains are relevant when evaluating the effects of treatment.
Although some GPs did not consider the patient's viewpoint relevant when evaluating the severity of the condition and patient benefit, most of them included patient worries and expected outcome.
Furthermore, baseline disease burden data are relevant when evaluating the introduction or expansion of vaccines, infection control measures, and hand washing and respiratory hygiene campaigns which aim to prevent and control respiratory virus transmission [ 7].
The overall proportion of ApoE4 carriers in these studies (>60%) is relevant when evaluating the safety of CAD106 in ApoE4 carriers, who have been reported to be at greater risk for ARIA-E following treatment with the passive amyloid immunotherapy bapineuzumab [ 23].
Specifically, although response probably remains the most widely used outcome measure, non-binary definitions or volumetric measures of response, measures of time to event or continuous markers such as biomarkers may be more relevant when evaluating the activity of targeted or cytostatic agents (Karrison et al, 2007; Booth et al, 2008; Adjei et al, 2009; Dhani et al, 2009; McShane et al, 2009).
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However, t98% is more relevant when evaluating degradation in terms of impurity limitations imposed by the ICH guidelines (ICH Guideline Q1A, R2 2003; ICH Guideline Q3A, R2 2006; ICH Guideline Q3B, R2 2006), and can therefore be more applicable for stability screening at later stages of the development.
Such time effects can also include seasonal variations and disease progression: the latter may be particularly relevant when evaluating interventions targeting treatments for HIV.
Kaplan Meier plots are also relevant when evaluating migraine treatments.
Lastly, Kaplan Meier plots, sometimes called survival curves, can be used as a graphically visual display of pain outcomes in migraineurs that can be relevant when evaluating different interventions.
This may also be relevant when evaluating imprinting defects after ART.
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