Sentence examples for relevant transporter from inspiring English sources

To investigate biophysical studies of this pharmacologically relevant transporter, we developed a mammalian expression system with tetracycline-inducible HEK293 cells using synthetic human SERT genes produced by PCR-based self-assembly method.

However, this form of the transporter has extremely restricted expression in humans (it has only been documented in the testis) [17] leading to the speculation that ABCB5 beta which has been reported to be the predominant form in melanoma and other cancers may possibly undergo dimerization to create the physiologically relevant transporter in these malignancies.

In contrast, the deletion strain for the quinate permease (Δ6026) was almost completely unable to take up qa, indicating that it is the only physiologically relevant transporter for this compound.

The current structures and functional data reveal a binding site that can accommodate peptides in different orientations that helps to explain the broad substrate specificity characteristic of this pharmaceutically relevant transporter family.

Those populations of neurons that were retrogradely labeled by fluorogold but did not show immunoreactivity for the relevant transporter markers did not significantly differ in size from the overall population of traced neurons (Table 2) and showed no other obvious morphological characteristics that would differentiate them from the population of traced cells that expressed the marker.

Molecular data on the relevant transporters in pollen tubes have been experimentally determined in Arabidopsis [12], [13].

It was recently highlighted by the International Transporter Consortium as one of the seven most relevant transporters for drug development due to its broad substrate specificity, potential for drug-drug interactions, and clinically relevant polymorphisms [49].

While progress has been made in elucidating the interplay between ions specifically by accumulating data on the relevant transporters experimentally in Arabidopsis [12], [13], understanding the more intricate features of pollen tube development requires the development of a model at a systemic level [12].

The model has to be extended to describe the kinetics of the transporters and the kinetics of gene expression for the relevant transporters.

These findings demonstrate that drug-drug interactions via relevant transporters may affect the distribution of cephalosporins in both brain ECF and ICF.

Consequently, the attenuation of PGE2 elimination cannot be explained simply in terms of changes in protein expression of relevant transporters at the BBB.