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Hence, we postulate that the full-length NS3 assay is a relevant system for inhibitor identification, offering new opportunities for inhibitor design.
Of additional note, the IL-32β transgenic mice may offer a better and more relevant system for studying human diseases, as we often observe partial and reduced phenotypes in rodent disease models compared to humans.
Thus, driving medicinal chemistry optimization in a cellular assay factors in cellular permeability and provides a physiologically relevant system for testing the inhibitor.
Silica nanoparticles (NPs) are a versatile, relevant system for various biomedical applications such as sensing, imaging, drug delivery, DNA carriers, and bioassays.
Arabidopsis thaliana has been established as a relevant system for the discovery of genes associated with response to herbivory, including genes for specialized (i.e. secondary) metabolism as well as genes involved in plant-insect defence signalling.
Despite the new system many physicians still find that information regarding imaging status influences their management so the Durie and Salmon PLUS is a more relevant system for radiologists.
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The review is structured for quick identification of relevant systems for the production of specific polymer architectures with specific cost, efficiency, and safety concerns.
Biodiesel or oxygenated fuel from renewable sources set a challenge to the engine technology to design relevant systems for keeping high efficiency and low environmental impact.
Recent and upcoming advances in light source capabilities are ideally suited to monitor light-generated transient structures and well-poised to dramatically impact the drive toward technologically relevant systems for artificial photosynthesis.
From these, we included 115 reports of 78 potentially relevant systems for a bioterrorism response (55 detection systems and 23 diagnostic decision support systems).
Mouse xenograft models of haematological malignancies, established by the transplantation of donor cells into non-obese diabetic/severe combined immunodeficient (NOD/SCID) or NOD/SCID/IL-2 receptor gamma chain−/− (NSG) mice, are recognised as one of the most clinically relevant systems for investigating leukaemia biology and testing new treatments [ 5– 12].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com