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The minimum duration of seizure freedom for 12 months has been added by the Task Force in order to obtain information, if a clinically relevant sustained effect occurred [ 1].
In addition, at Years 1 and 3, respectively, 56 (40%) of 139 and 35 (47%) of 74 patients who had a ≥50% decrease in seizures at 3 months and had remained in the study were now seizure-free (100% responders), indicating a clinically relevant sustained or increased response.
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The absence of audiovisual crossmodulation frequencies suggests that the previously reported audiovisual interactions in primary sensory areas may mediate low level spatiotemporal coincidence detection that is prominent for stimulus transients but less relevant for sustained SSR responses.
A proximal muscle weakness was considered present, relevant and sustained if it was observed by the investigator and physiotherapist performing the 8-MMT with one month between the two testings.
The observed 4 mmHg increase in systolic blood pressure is considered clinically relevant if sustained in the long-term, since recent studies have demonstrated that every 1 mmHg increase in systolic blood pressure in elderly with isolated systolic hypertension is associated with a 1%% increase new onset heart failure [ 16].
While we found a general domain of an "ongoing focus on sustainability", there were few references to how the other domains were relevant to sustaining delivery at scale.
Additionally, studies seeking to investigate the effects of resistance training for improved performance of flexor and extensor forearm muscles can be relevant for sustaining grip during Brazilian jiu-jitsu matches, given that grip power provides a more effective form of controlling the adversary.
Taken together, these results highlight the capacity of c-Fos to activate phospholipid synthesis as relevant to sustain proliferation and growth of adult brain tumor cells.
This type of BDNF effect is thought to be particularly relevant for sustaining neuropathic pain.
BAFF secretion could be relevant in sustaining intrathecal B cell responses in autoimmune and infectious diseases of the central nervous system.
Implementers, funders, and the communities served need to assess what strategies and practices of scaling up are also relevant for sustaining delivery at scale.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com