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This is an early, although still relevant, summary of the statistical modelling of drug efficacy effects.
All relevant summary statistics from the ABCFS, HEBCS and POSH cohorts are available from the authors for collaborative research upon request to the corresponding author.
This study compares the two charts and their ability to visually portray the various relevant summary statistics that assess how good a diagnostic test may be, such as sensitivity, specificity, predictive values, and likelihood ratios.
Relevant summary statistics are provided in Table 1.
Fugh-Berman says review articles are also popular because busy physicians rely on experts to synthesize the medical literature and provide a clinically relevant summary.
Following Junge et al. (2014), we accordingly divide our sample to separately consider the subsample where the female is the primary earner and the subsample where the male is the primary earner (see Appendix Table 7 for relevant summary statistics).
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Among the 43 relevant summaries stating that the DRD4 gene is significantly associated with ADHD only 6 mentioned that the 7-repeat allele confers a small risk.
For methylphenidate and other stimulants specific figures are not publically available however the relevant summaries of product characteristics (SPC) provide advice for and mandate monitoring [ 4].
The availability of relevant summaries within guidelines, as well as target dissemination to less experienced clinicians, along with the provision of clear and concise information to patients, are possible solutions to enhance guidelines implementation among clinicians.
Clinicians can also seek independent advice on suicidality from national guidance (in the United Kingdom this would be NICE and SIGN), relevant summaries of product characteristics (SPC), European expert groups and other worldwide developed guidance [ 3, 8- 11].
All drugs granted pediatric exclusivity under the FDAMA were analyzed by studying the relevant summaries of medical and clinical pharmacology reviews of the pediatric studies or, if these were unavailable, the labeling information as provided by the manufacturer.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com