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Relevant study design should consider appropriate repetitions based on the range of values of the studied factors.
A total of two articles (Anderson et al. 2008; Luchetti et al. 2014) with relevant study design and outcome measures comparing open vs arthroscopic repair of the TFCC were identified and subsequently included in this systematic review.
Indeed, some trials used a clinically relevant study design but did not explicitly justify their choice.
Fifthly, our definition of what constitutes a clinically relevant study design may be challenged.
In this scenario, a case- control study is a relevant study design.
The Quality Assessment of Diagnostic Accuracy Studies (QUADAS)[ 6] quality assessment tool was used to evaluate the relevant study design characteristics of each study.
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2) The tool covers randomized controlled trials being one of the relevant study designs.
Many of the published instruments focus on experimental study designs, but do not cover other relevant study designs, such as diagnostic studies or qualitative studies.
Both aetiology and prognosis relate to an identification of risk factors for an outcome and so the relevant study designs are quite similar.
We start with a brief overview of relevant study designs and models, before we discuss relevant studies with the specific environmental chemicals, followed by a review of some potential mechanisms involved.
Since the study design also depends on the endpoints to be measured this section discusses not only how to identify potential intervention targets and outcomes but also relevant study designs.
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