This route was used because it is considered relevant for stimulating the mucosal tissues [ 56, 57].
Political involvement seems to be relevant in stimulating GPs' interest in this field as well as wider patient recognition of GPs as reproductive health care providers.
Estrogen at this physiologically relevant concentration stimulated the colony growth approximately twofold.
This can be extremely relevant to stimulate the broadest and most qualified participation in collaborative efforts.
Taken together, these observations suggest that excessive doses of morphine may inhibit angiogenesis because of their nonspecific cytotoxicity, whereas physiologically relevant doses stimulate angiogenesis via OR-mediated activity.
It has been demonstrated that morphine at clinically relevant doses stimulates angiogenesis in vitro [ 20], promotes tumour growth in breast cancer mouse model, and increases vascular permeability [ 21].
Two weeks of chronic morphine treatment at clinically relevant doses stimulates COX-2 and PGE2 (4.5-fold compared to vehicle alone) and angiogenesis in breast tumours in mice.
Based on this, it seems relevant to stimulate active commuting among the African-Surinamese and South Asian-Surinamese in the Netherlands in both low and high socioeconomic position groups.
According to some studies, morphine at clinically relevant doses stimulated angiogenesis in vitro [ 20] and tumour growth in breast cancer mouse model [ 21].
In the present study, we examined whether low concentrations of BPA (10 12 to 10 7 M), which are environmentally relevant, can stimulate proliferation of GC-1 cells via such a nongenomic action and, if so, whether GPR30 or its combination with ER-α is involved in the proliferation.
