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Concerning the voids, the relevant signature of the resistivity dipoles is the decay of the dipole outside of the actual void, namely on the surrounding flat terrace where also no significant change in the sample topography is present, which could lead to tip jumping.
As illustrated in Figure 2, we observed significant and clinically relevant signature performance, precision greater than 0.80, for twelve out of fifteen drugs.
Although we have used this method to derive a compact and clinically relevant signature of hypoxia in cancer, the approach is likely to have broader applicability.
The procedure renders a set of relevant signature genes that contains false positives with probability α (for a predefined error level α).
In addition, by design, we focused solely on adenocarcinoma histology to provide the most relevant signature for the vast majority of cases of esophageal cancer in the West.
We can see that the differential analysis indeed has the power to identify the most relevant signature genes for the predicting task (P value = 3.39 × 10−5; t-test).
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To do so, we will select the L most relevant signatures using model order selection techniques [30].
In these circumstances, and in order to improve the spectrum sensing detection performance, we need to select the relevant signatures of active sensors so that the rest of K - L signatures can reasonably be ignored.
These datasets are important for two reasons: first, they have been used to derive both clinically relevant signatures and to investigate underlying biological processes [8], [9], [18], [20] [22], [24].
As such, it should be possible to develop an algorithm that evaluated each of the relevant signatures (total body, partial body by site) to then make a determination of the health status of the individual.
This will increase the statistical power to detect disease relevant signatures in patient-control studies.
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