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The phenomenon of super-additivity of the therapeutic effect of a combination, known as synergy, has the potential for improved pharmaceutical treatment options in terms of increased efficacy [5] and therapeutically relevant selectivity [6], whilst reducing the risk of toxicity [7] and side-effects [8].
Thus, selecting proper drug combinations that can yield a synergistic effect is thought to be an effective way of countering biological buffering and increasing therapeutically relevant selectivity.
These finding support the emerging idea that synergistic combinations of some agents can overcome toxicity and other side-effects associated with high doses of single drugs creating the opportunity for therapeutically relevant selectivity.
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Table 1 Relevant selectivities of anion exhange resins used in this study Selectivity with respect to OH- Ion AG1-X8 AG22X8 Cl- 22 2.3 SO42-, HSO4- 85 15 S2O32- ≈275 ≈90 S x O62- (n > 2) Fully retained ≈500.
A profile is emerging that suggests that HMMs process information with less goal-relevant selectivity in both visual search (Cain & Mitroff, 2011; Lui & Wong, 2012) and working memory tasks (Ophir et al., 2009; Sanbonmatsu, Strayer, Medeiros-Ward, & Watson, 2013).
Given a detailed analysis of the inhibitor SAR for both transporters the two structural models of SGLT1 and SGLT2 were compared leading to the identification of relevant differences and selectivity hot spots.
Exploiting the longitudinal nature of his data, Moretti can address the most relevant endogeneity and selectivity issues by including plant and city fixed effects: however, his data cannot conclusively rule out the possibility that time-varying productivity shocks are correlated with changes in the overall level of human capital in a city.
Also note that, while oxidant coverage will have an effect on all elementary steps, only the effects on the steps relevant to the selectivity have been calculated.
The binding modes from which chemical modification of a substrate is possible are the most relevant for understanding enzyme selectivity and for the rational enzyme engineering.
Finally, we calculated time needed (FWIT/A), naming skills (FWIT/N), selectivity of relevant information (FWIT/S), and number of errors on the interference task (FWIT/E).
The potential to silence the expression of any cancer-relevant protein with high selectivity promotes RNAi therapeutics as a more effective and safer treatment to traditional approaches.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com