The EAC attempted to overcome the limitation in comparative studies by conducting a literature review to identify relevant conventional rod studies and by undertaking meta-analysis on outcomes reported in these studies.
This was particularly relevant for larger rods, with diameters of 5, 4, and 3 mm, whereas it was not observed in rods with diameters of 2, 1, and 0.5 mm.
Moreover, we also analyzed a highly expressed retinal gene that has been reported to show circadian rhythmicity (Rho) (von Schantz et al., 1999), plus three transcription factors that are relevant for cone-rod fate and function and might be sensitive to light/dark conditions (Fig. 1C).
Nonetheless, several retinal transcription factors (TFs) relevant for cone and rod fate, as well as some circadian rhythm regulators, are regulated by sumoylation.
On the other hand, several regulatory circadian rhythm genes, as well as transcription factors (TFs) relevant for cone and rod differentiation, such as NR2E3 and NRL, are regulated by sumoylation (Onishi et al., 2009; Roger et al., 2010; Wright et al., 2004), indicating that the SUMO pathway is important in retinal physiological function.
Both single and dual conventional rod constructs were relevant.
With further refinements of drug release rate, these rods may offer a clinically relevant alternative for intrathecal analgesia.
In this paper we extend the rod model by incorporating the practically relevant temperature dependencies and aerodynamic forces.
Our results show that for realistic values of Ih conductance the dynamic range is enhanced by rod-rod coupling, and that AII-AII coupling is less relevant to dynamic range amplification in comparison with receptor coupling.
The External Assessment Centre (EAC) identified 16 conventional growth rod studies and undertook meta-analyses of relevant outcomes.
