Although the ISSCR guidelines do not provide a rationale for this prohibition, the only potentially relevant rationale articulated in the accompanying commentary cites a concern for the creation of "humanized cognition, awareness, or other mental attributes" (Hyun et al. 2007, 162).
Evaluation of obtained data would provide scientific rationale for relevant cancer immunotherapy; it will be vitally important to evaluate how appropriate the clinical development itself is and to determine whether to continue or discontinue the development.
This literature search forms the rationale for the relevant stages of the assessment guideline.
The multi-sector programme approach proved to be relevant in practice, though the rationale for such an approach was not sufficiently made explicit in the programme document.
The meeting agenda included: a review of relevant evidence, discussion of the rationale for including or excluding items in a PRO reporting standards checklist from the point of view of the multiple stakeholders at the table, anonymous voting on the proposed standards, the development of a draft CONSORT extension, and the development of a knowledge translation and dissemination strategy [ 13, 14].
The physician will spend approximately 30 min with each subject explaining the rationale for the injection, relevant anatomy, performing the procedure and reviewing the pendulum exercises.
These activities clearly suggest that a considerable effort was made to engage with relevant stakeholders and promote a coherent rationale for service redesign.
Taken together, our data indicate that ADI-PEG 20 and cisplatin will complement each other in a clinically relevant heterogeneous tumor, thus providing a rationale for combining these two drugs for the treatment of HCC.
Relevant literature was analysed to find a mechanistic rationale for the mined features, which resulted in four new structural alerts for in vitro mutagenicity.
However still this leaves little objective rationale for distinguishing the more empirically relevant loci from those whose effects are confined to only certain genetic backgrounds.
