Although the ISSCR guidelines do not provide a rationale for this prohibition, the only potentially relevant rationale articulated in the accompanying commentary cites a concern for the creation of "humanized cognition, awareness, or other mental attributes" (Hyun et al. 2007, 162).
Thus, H3 modulation seems to be a relevant rationale for manipulating BCRP expression; however, this needs to be examined further because HDACi such as romidepsin has not induced BCRP mRNA expression in all cell lines studied so far [226].
Targeting FPR1 with CHIPS has a relevant clinical rationale due to its interaction with other pathways involved in shaping the aggressive phenotype of glioblastoma.
Key parameters for these musculoskeletal interfaces, such as relevant design rationales, the structure function relationships, and the formation and maintenance of multitissue systems, will be reviewed and discussed.
To date, there is no relevant evidence-based rationale to explain any potential IDeg-associated cardiovascular risk.
Herein, the authors summarize relevant preclinical data and rationale supporting the synergy of combined RT and immunotherapy and highlight recent clinical work on promising combination strategies.
Selecting the appropriate methods requires first identifying the relevant scientific question and rationale, with an important distinction made between analyses aiming to characterize the joint effects of putative or established genetic and environmental factors and analyses aiming to discover novel risk factors or novel interaction effects.
In addition, it provides a detailed explanation to accompany each recommendation, supported by a rationale and relevant evidence where available.
Evaluation of obtained data would provide scientific rationale for relevant cancer immunotherapy; it will be vitally important to evaluate how appropriate the clinical development itself is and to determine whether to continue or discontinue the development.
The White Paper delves much deeper into the legal and policy rationales for controlled digital lending, reviewing relevant law, the fair use rationale for CDL, and practical risk and policy considerations for libraries that might consider implementing CDL for some parts of their collections.
Neither of these rationales is relevant to foster carers, who are required to have a spare room in order to provide homes for vulnerable children".
