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Enrichment analysis can also help identify relevant pathways and improve mechanistic understanding of underlying neurobiology [7, 11, 15, 19].
These studies demonstrated that clinical-biological phenotyping may help unravel relevant pathways in asthma beyond inflammation [73].
As with any data mining exercise, manual curating of data is inherently time-consuming and requires considerable knowledge of relevant pathways and principles.
Thus, some therapies targeting these relevant pathways have been widely investigated regarding their potential to attenuate the damage caused by migraine [10, 11].
Because ABL played only a minor role in the inhibitory effect of Ponatinib on metastasis-associated gene expression, we investigated relevant pathways in drug-treated LM2 cells.
Additionally, efforts have been made to develop computational methods for the integration of microRNA, microRNA targets, and transcription factors into biologically relevant pathways, circuits, and networks [46, 47].
Changes in gene-expression profiles after HBO suggested several relevant pathways to be involved.
In many other diseases the relevant pathways are not yet as clearly identified.
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There are 3,000 pathway annotations of relevance to cellular systems, including immune-relevant pathways.
Ingenuity revealed that the differentially expressed genes might play a role in several cancer-relevant pathways (Table 1).
SNP309 might therefore affect several cancer-relevant pathways.
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