Transgenic over-expression of defence peptide genes is potentially useful to engineer resistance of plants to relevant pathogens.
Hence efflux pump inhibition, as a means to reverse antimicrobial resistance in clinically relevant pathogens, has gained increased momentum over the past two decades.
In the future, vaccines need to be developed against deadly diseases for which this strategy is often not feasible because of the extensive antigenic variability of relevant pathogens.
The resulting library has been tested for antimicrobial activity against a wide range of clinically relevant pathogens as well as for toxicity to red blood cells.
The results obtained suggest that the newly synthesized compound is effective in treating the relevant pathogens and is suitable in designing new effective antimicrobial preparations.
DC-SIGN (dendritic cell-specific ICAM-3-grabbing non-integrin) is a myeloid pathogen-attachment factor C-type lectin which recognizes mannose- and fucose-containing oligosaccharide ligands on clinically relevant pathogens.
When antagonistic activity of isolated LAB against bovine relevant pathogens was evaluated, organic acids and hydrogen peroxide production were mostly responsible for inhibition; bacteriocin production was shown only by a Lb.
Here, we used crosslinking immunoprecipitation (CLIP) of the Argonaute (AGO) proteins to characterize strengths and specificities of miRNA interactions in the context of 15 different RNA virus infections, including several clinically relevant pathogens.
Here we sought to (1) determine the relative efficacy of ZnO-NPs on planktonic growth of medically relevant pathogens; (2) establish the role of bacterial surface chemistry on ZnO-NP effectiveness; (3) evaluate NP shape as a factor in the dose response; and (4) evaluate layer-by-layer (LBL) ZnO-NP surface coatings on biofilm growth.
Since then, studies have generally selected doses designed to achieve lung concentrations that far exceed the MIC of relevant pathogens in the lung [41, 49].
Together, these data contribute to our understanding of the range of bacterial inhibition exhibited by this novel micro-pattern against several clinically relevant pathogens and conditions.
