Sentence examples for relevant mutation from inspiring English sources

To determine the sensitivity and precision of our DDiMAP approach, we used the Sanger-level IGH private sequence information from a highly mutated FL case as a biologically relevant mutation pattern in a simulation study incorporating both ongoing mutation from the initial sequence and simulated Illumina HiSeq error patterns in 100 base pair single-ended reads [ 47].

Accurately estimating Nμ, which is closely related to the widely used parameter θ in population genetics, for natural populations is difficult [ 30, 31] (note that as mutational robustness is a protein-wide property, the relevant mutation rate is per protein, which is ≈ 102 to 103 larger than the per codon mutation rate).

At the moment, many targeted cancer drugs are accompanied by a diagnostic test for the relevant mutation.

Their precarious condition means they are rarely accepted for phase II and III trials, which are more complicated and extensive.Oddly, though, even if the drug being tested is a targeted therapy the tradition in phase I trials has been to gather together patients with, say, lung cancer and assume that all carry the relevant mutation.

Fig. 7 Residue charges in protegrin-1 (PG1) indicate relevant mutation sites.

Second, the relevant mutation rates are much, much higher in the immune system than in ordinary gene-based selection.

Furthermore, clinically relevant mutations may be even introduced or replaced by a non-mutated sequence when one of the exon 6 variants itself is affected.

In recent years, a number of mutational profiling studies have attempted to further identify clinically relevant mutations.

The relevant mutations are still scattered among different strains.

Even if we don't have the relevant mutations ourselves, we can learn from what the mutations tell us about the nature of sleep.

So is vemurafenib, a new drug against malignant melanoma.The problem is that identifying the relevant mutations is hard.