Sentence examples similar to relevant lifespan from inspiring English sources

Hyperoxia induces features of premature senescence in many laboratory systems, and can provide a reproducible test of metabolic stress resistance that often, but not without exception [39], [57], is relevant to lifespan in a general way [36] [38].

This will pave the way to identify loci relevant for lifespan and fully make use of N. furzeri as an alternative genetic vertebrate model for age research.

The regulation of systemic IIS by local dfoxo can still be relevant to lifespan as part of a positive feedback loop.

These results indicate that the activity of tph-1 and daf-7 in these respective neurons are relevant to lifespan modulation.

However the respective role of different KL isoforms in aging and the molecular mechanisms altered in transgenic mice that are functionally relevant for lifespan regulation are still poorly understood.

However, not always overexpression of antioxidant enzymes may be relevant for the lifespan.

These data suggest that S6K1 plays a relevant role in lifespan regulation downstream of TORC1.

Overall those data support the idea that the regulation of IIRc pathway by KL is conserved between C. elegans and mammals and that this pathway constitutes a relevant target for lifespan control by KL in mice.

Accelerated disease progression in these dko mice provides an excellent opportunity not only to obtain results from experimental therapies more rapidly but also to confirm whether a therapy can indeed ameliorate clinically relevant manifestations and increase lifespan.

In fact, treatments able to correct the systemic disease associated with GLD, such as HCT, alone or in combination with systemic delivery of GALC-expressing vectors (14, 20– 23) as well as novel HSC GT protocols (50), significantly extend the lifespan of relevant GLD models.

It will therefore be important to test whether the lifespan-relevant interactions between Foxo and Aop occur on promoters where Foxo acts as a repressor with Foxo possibly acting as a cofactor for Aop or vice versa.