Sentence examples for relevant inducers from inspiring English sources

This study reports the experimental conditions required to induce fibrosis associated with steatohepatitis using physiologically relevant inducers.

When SecCell was inducibly expressed in sender cells, that were co-encapsulated with producer cell lines expressing therapeutic proteins, the removal of relevant inducer molecules enabled the time-dependent discharge of these therapeutic proteins, the kinetics of which could be modified by varying the concentration of inducer molecules or the amount of encapsulated sender cells.

Consequently, "bulk" NK cells were first activated with interferon α (IFNα), a physiologically relevant inducer of TRAIL during viral infection in vivo (Sato et al., 2001; Takeda et al., 2001).

Free fatty acids (FFAs) are physiologically more relevant ER stress inducers in beta cells [33], [34], [35].

This finding is clinically relevant since many autophagy inducers are currently under clinical investigation for the treatment of several diseases and aging.

Patients were also ineligible if they had a recent history (within 3 months) of active keratitis or keratoconjunctivitis, clinically active brain metastases, prior hepatic resections or hepatic-directed therapies, or had used medication or food that was a clinically relevant CYP3A inhibitor or inducer within 2 weeks prior to the first dose of study treatment.

Also, further studies are now required to establish whether praeruptorins have a clinically relevant metabolic interaction with CYP enzyme inducers and/or inhibitors to avoid or reduce CYP-mediated drug interactions and to optimiz dosing and duration of therapy to prevent subtherapeutic effects or toxicity.

None of the drugs used is known to be a strong inhibitor or inducer of the enzymes relevant in the pharmacokinetics of dexmedetomidine.

In view of the interactions between S100 proteins and TGFβ1, and the fact that TGFβ1 is a well known inducer of EMT, a relevant biological phenomenon in morphogenesis and in cancer initiation and progression, we ascertained whether the observed molecular interactions also occur in this process.

We also investigated growth conditions on D-glucose as this is certainly industrially relevant (enzyme production on high glucose-containing inducers).

Compound 36 is neither an inducer nor an inhibitor of relevant cytochrome P450 isoforms.