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Blinding of patients, personnel, and outcome assessors was not assessed because these items are less relevant in the setting of a surgical trial with unequivocal outcomes and a long follow-up period.
This was particularly relevant in the setting of an upcoming review by the Liaison Committee on Medical Education.
Several side effects were observed in our patients, two of which are particularly relevant in the setting of neurosurgical patients.
Unveiling such factors could be particularly relevant in the setting of new therapeutic options acting through angiogenesis modulation.
These issues are also relevant in the setting of current developments of genomic multi-step or single-step prediction methods (e.g., [ 3- 5]).
The issue of test sensitivity is particularly relevant in the setting of selective antibiotic pressure, as has been demonstrated in the case of VRE [ 44- 47].
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The level of clinical acuity may deem a patient susceptible to developing clinically relevant AKI in the setting of an offending agent, and furthermore, once AKI develops, it may be more poorly tolerated, posing a greater contributor to mortality.
This observation has pointed to short telomere length as the relevant lesion in the setting of mutant telomerase genes, and more commonly, because telomere length is polymorphic, as an important genetic determinant of age-related disease [17].
Taken together, these data suggest that ER-mediated signaling remains relevant even in the setting of endocrine resistance.
In this review, biomarkers relevant to the setting of metastatic prostate cancer are discussed with respect to a number of key attributes critical for clinical development of non-invasive, actionable markers.
These experimental conditions may significantly affect cardiovascular mechanics, but we considered them relevant to the setting of cardiac surgery, in which RV dysfunction is an important risk factor for perioperative mortality [ 45].
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