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Blinding of patients, personnel, and outcome assessors was not assessed because these items are less relevant in the setting of a surgical trial with unequivocal outcomes and a long follow-up period.
This was particularly relevant in the setting of an upcoming review by the Liaison Committee on Medical Education.
Several side effects were observed in our patients, two of which are particularly relevant in the setting of neurosurgical patients.
Unveiling such factors could be particularly relevant in the setting of new therapeutic options acting through angiogenesis modulation.
These issues are also relevant in the setting of current developments of genomic multi-step or single-step prediction methods (e.g., [ 3- 5]).
The issue of test sensitivity is particularly relevant in the setting of selective antibiotic pressure, as has been demonstrated in the case of VRE [ 44- 47].
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Because antimicrobials are frequently prescribed in the ICU, stewardship is particularly relevant in this setting because it provides the framework necessary to improve the quality of antimicrobial use.
Most clinically relevant in this setting is the reactivation of HBV, which can occur in up to 50%% of patients with previous hepatitis B [ 37– 40].
However, owing to the nature of diseases encountered in ICUs, interventions that are successful in other settings may not be relevant in the ICU setting.
The level of clinical acuity may deem a patient susceptible to developing clinically relevant AKI in the setting of an offending agent, and furthermore, once AKI develops, it may be more poorly tolerated, posing a greater contributor to mortality.
This observation has pointed to short telomere length as the relevant lesion in the setting of mutant telomerase genes, and more commonly, because telomere length is polymorphic, as an important genetic determinant of age-related disease [17].
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